Molecularly imprinted hydrophilic polymer sorbents for selective sorption of erythromycin
Ezhova, N.M.; Garkushina, I.S.; Pisarev, O.A.
Prikladnaia Biokhimiia i Mikrobiologiia 47(6): 694-698
2011
ISSN/ISBN: 0555-1099 PMID: 22288199 Document Number: 655304
New hydrophilic polymer sorbents comprising reactionary sites which are complementary to a molecule of antibiotic erythromycin were synthesized by the method of molecular imprinting. A series of similar sorbents without reactionary sites was used for comparison of sorption characteristics. Sorption of erythromycin on both types of polymer sorbents synthesized was studied in a wide range of pH and ionic strength. Selectivity of erythromycin sorption on molecularly imprinted cross-linked polymers was shown to depend on the specific interaction of target molecule with polymer matrix. This type of sorbent is perspective for the development of antibiotic purification directly from a culture medium Saccharopolyspora erythreus.