N-Didemethyl-n-propionyl-6,9;9, 12-erythromycin A-spiroketal, a new metabolite of erythromycin ethyl succinate in man
Majer, J.; Stanaszek, R.S.; Mueller, S.L.; Marti, G.
Drug Metabolism and Disposition the Biological Fate of Chemicals 6(6): 673-676
1978
ISSN/ISBN: 0090-9556 PMID: 33030 Document Number: 129699
A novel, neutral metabolite of erythromycin was isolated from the urine of a patient treated with erythromycin ethyl succinate. After separation and purification on Sephadex LH-20 column chromatography, the structure of the metabolite was deduced from spectral data to be the propionamide of the didemethylated 6,9;9, 12-spiroketal of erythromycin A.