Comparison of the mechanism of action of cyclic 11,12-erythromycin a carbonate and erythromycin a
Klita, S.; Szafranśki, P.
Acta Biochimica Polonica 27(3-4): 213-220
1980
ISSN/ISBN: 0001-527X PMID: 7023159 Document Number: 163807
Synthesis of polyphenylalanine and polylysine in the E. coli MRE 600 and Q 13 cell-free systems was inhibited by erythromycin A and cyclic 11, 12-erythromycin A carbonate to a similar or identical extent. Both compounds inhibited translation of phage f2 RNA in the E. coli Q13 cell-free system. Neither antibiotic affected binding of initiator tRNA or phage f2 RNA to E. coli ribosomes, and neither inhibited translation of BMV RNA in the wheat-germ cell-free system.