Effect of fullerene C60 on functional activity of phagocytic cells
Vesnina, L.É; Mamontova, T.V.; Mikitiuk, M.V.; Kutsenko, N.L.; Kutsenko, L.A.; Bobrova, N.A.; Berkalo, L.V.; KaÄdashev, I.P.
Eksperimental'naia i Klinicheskaia Farmakologiia 74(6): 26-29
2011
ISSN/ISBN: 0869-2092 PMID: 21870772 Document Number: 654110
The effect of aqueous dispersion of fullerene C60 (FC60) on the functional activity of cells involved in the phagocytosis reactions was studied. FC60 (0.01 microM/l and 0.1 microM/l) produced mainly negative effects on the activity ofnonspecific immunity cells by inhibiting the myeloperoxidase enzymatic activity, decreased the level of induced chemiluminescence, and suppressed the expression of molecules CD54 involved in the adhesion. The only exception was a slight stimulating effect on the NBT test. The results indicate the FC60 influences various stages and mechanisms of phagocytosis.