Mitotane as possible cause of acute intermittent porphyria
Von Eyben, F.E.
Ugeskrift for Laeger 173(37): 2268-2269
2011
ISSN/ISBN: 1603-6824 PMID: 21917227 Document Number: 653873
A 54 year-old woman with acute intermittent porphyria (AIP) developed an attack of porphyria after 156 days of treatment with mitotane following a non-radical adrenalectomy for adrenocortical carcinoma. Mitotane therapy was discontinued but the attack of porphyria persisted for more than four months and included episodes with severe metabolic and neurologic toxicities. Mitotane is probably porphyrinogenic for patients with AIP.