Intestinal endotoxin in induction of type 1 diabetes
Okorokov, P.L.; Anikhovskaia, I.A.; Volkov, I.E.; Iakovlev, M.I.
Fiziologiia Cheloveka 37(2): 138-141
2011
ISSN/ISBN: 0131-1646 PMID: 21542330 Document Number: 652663
We studied serum level of intestinal flora endotoxin (LPS) in 45 children and adolescents aged 3-17 years old with diabetes mellitus type 1. Levels of endotoxin, were significantly elevated in type 1 diabetic patients (2.89 +/- 0.33 Eu/ml) compared with control (0.4 +/- 0.03 Eu/ml). There was significant difference in serum LPS levels in patients with type 1 diabetes onset (3.93 +/- 0.79 Eu/ml) compared with children and adolescent with old time diabetes (2.37 +/- 0.27 Eu/ml). These results have a major implication on our understanding of the role of gut flora endotoxin in pathogenesis of type 1 diabetes.
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