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Induction of endothelial tissue factor by endotoxin and its precursors

Moldow, C.F.; Bach, R.R.; Staskus, K.; Rick, P.D.

Thrombosis and Haemostasis 70(4): 702-706

1993

ISSN/ISBN: 0340-6245
PMID: 8116000
Document Number: 410634
The structural determinants of lipopolysaccharide required for the induction of tissue factor in human umbilical vein endothelial cells were studied. Intact lipid A was essential for the induction of tissue factor whereas the incomplete lipid A precursors lipid IV-A and lipid X, as well as monophosphoryl lipid A and acyloxyacyl hydrolase-treated lipopolysaccharide, were unable to induce tissue factor and tissue factor specific mRNA. However, the lipid A precursor, lipid IV-A, was able to inhibit LPS-mediated induction of tissue factor; structural determinants distal to lipid A were found to be required for maximal induction of tissue factor activity and tissue factor mRNA. The presence of serum in the assay was found to amplify but was not obligate for tissue factor induction by LPS.

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