Morphological analysis of bone dynamics and metabolic bone disease. Pathophisiology of Microdamage
Mori, S.
Clinical Calcium 21(4): 559-565
2011
ISSN/ISBN: 0917-5857 PMID: 21447923 Document Number: 650581
Microdamage, small crack in bone, is a product of bone fatigue. Burden of microdamage in vivo bone is determined by balance of generation and repair of microdamage. It has been reported that aging, bone loss, coarse osteocyte network, reduced bone remodeling cause accumulation of microdamage in bone. It is suspected that insufficiency fractures of subtrochanteric femur in patients under long term bisphophonate treatment are caused by severely suppressed bone turnover.