Methabolism of connective tissue in patients with complicated chronic pancreatitis
Krivoruchko, I.A.; Boĭko, V.V.; Zhukov, V.I.; Goncharova, N.N.; Andreeshchev, S.A.; Moiseenko, A.S.
Klinichna Khirurhiia 10: 10-14
2011
ISSN/ISBN: 0023-2130 PMID: 22295542 Document Number: 650579
A content in the blood serum of a free and connected oxyproline, collagenolytic activity of the blood, the level of glycosaminoglycans and elastase activity was detected in chronic pancreatitis (CHP). There were examined 73 patients (64 men and 9 women). CHP in a stage B (according to M. Buchler et al., 2009) was established in 26 (35.6%) patients, C1 - in 18 (24.6%), C2 - in 17 (23.4%), C3 - in 12 (16.4%). A progress of pancreatic fibrosis in CHP have occurred on a background of a high activity of elastase in neutrophils, a glycosaminoglycans level raising, as well as a free and connected oxyproline. A detection of a neutrophils elastase activity and oxyproline content in the blood serum may be used in a clinical practice as additional diagnostic criteria of estimation of the pancreatic pathology severity. The changes revealed were the same as in CHP of alcoholic and of the other nature.