The alteration of proteins glycosylation in liver diseases
Chrostek, L.; Cylwik, B.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 31(181): 60-64
2011
ISSN/ISBN: 1426-9686 PMID: 21870713 Document Number: 650079
The changes in protein glycosylation play an important role in the pathogenesis and progression of various liver diseases. In the different types of liver diseases the same type of alterations seems to reappear. They are: hyperfucosylation, increased branching and the presence of increased bisecting N-acetylglucosamine of glycans. For these modification are responsible the activities of different glycosyltransferases, that are generally increased in liver diseases. However, the changes in the glycans structure of serum proteins are characteristic in the liver diseases of different etiologies and therefore could be potentially used in the diagnostics of liver pathology