Top Abstract Purchase Related
Home
>
Node
>
Subnode

Preparation and in vitro anticancer activity of oxymatrine mixed micellar nanoparticles

Jin, N.; Zhao, Y-Xing.; Deng, S-Hua.; Sun, Q.

Die Pharmazie 66(7): 506-510

2011

ISSN/ISBN: 0031-7144
PMID: 21812325
Document Number: 649596
The aim of this study was to prepare oxymatrine (OMT) mixed micellar nanoparticles to delay release of the drug and enhance its cytotoxicity against cancer cells. A co-solvent evaporation method using lipoid E80, lipoid S75, MPEG-PLA and Poloxamer 188 was chosen to prepare the OMT formulation, and its release characteristics, cytotoxic activity in vitro and physical characteristics were evaluated. The results showed that OMT mixed micellar nanoparticles have sustained release and cytotoxic activity in vitro to the SMMC-7721 cell line.

Document emailed within 1 workday
Secure & encrypted payments

Chen, D-Fei.; Zhu, Y-Qin.; Zhang, Y.; Wang, L-Yan.; Wei, Y-Hui. 2017: Preparation and in vitro evaluation of rhein-loaded PEG-PCL-PEI nanoparticles Zhongguo Zhong Yao Za Zhi 42(16): 3121-3130
Zhao, J.; Shan, X.; Sheng, Y.; Wu, F.; Yuan, Y.; Liu, C. 2008: Preparation of hemoglobin-loaded nanoparticles and safety evaluation in vitro and in vivo Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 25(3): 584-588
Tang, J.; Liu, J.; Hu, T-Ting.; Yang, C-Li.; Guo, G.; He, G.; Huang, Y.; Zheng, Y. 2013: Preparation and in vitro evaluation of pDNA-CaPi-PLGA nanoparticles with a core-shell structure Yao Xue Xue Bao 48(2): 298-304
Zhang, S-Juan.; Zhang, Y-Tai.; Zhao, J-Hui.; Shen, L-Na.; Shi, F.; Feng, N-Ping. 2013: Preparation and in vitro anti-tumor properties of toad venom extract-loaded solid lipid nanoparticles Die Pharmazie 68(8): 653-660
Ma, B.; Yan, W.; Chen, J.; Qi, P.; Li, J.; Huang, N. 2016: Preparation of Biological Functional Magnetic Nanoparticles and Study on the Effect of Guiding Endothelial Progenitor Cells In Vitro Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 33(1): 136-143
Yu, C.L.; Tsai, M.H. 2001: Embryonic apoptosis-inducing proteins exhibited anticancer activity in vitro and in vivo Anticancer Research 21(3b): 1839-1856
Sahoo, S.K.; Sahoo, S.K.; Behera, A.; Patil, S.V.; Panda, S.K. 2013: Formulation, in vitro drug release study and anticancer activity of 5-fluorouracil loaded gellan gum microbeads Acta Poloniae Pharmaceutica 70(1): 123-127
Johnstone, S.A.; Gelmon, K.; Mayer, L.D.; Hancock, R.E.; Bally, M.B. 2000: In vitro characterization of the anticancer activity of membrane-active cationic peptides. I. Peptide-mediated cytotoxicity and peptide-enhanced cytotoxic activity of doxorubicin against wild-type and p-glycoprotein over-expressing tumor cell lines Anti-Cancer Drug Design 15(2): 151-160
Loriga, M.; Fiore, M.; Sanna, P.; Paglietti, G. 1996: Quinoxaline chemistry. Part 5. 2-(R)-benzylaminoquinoxalines as nonclassical antifolate agents. Synthesis and evaluation of in vitro anticancer activity Farmaco 51(8-9): 559-568
Pellini, M.; Pellegrini, V. 1980: New therapeutic trends in vulvovaginitis caused by mixed bacterial flora. Controlled clinical study of a new preparation with trichomonocidal and antimycotic activity Minerva Ginecologica 32(3): 229-234
Loriga, M.; Moro, P.; Sanna, P.; Paglietti, G.; Zanetti, S. 1997: Quinoxaline chemistry. Part 8. 2-[Anilino]-3-[carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity Farmaco 52(8-9): 531-537
Duan, Y.; Zhang, Z.; Tang, Y.; Lin, Y. 2004: Preparation and degradation behavior of PELGE nanoparticles Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 21(6): 921-925
Belcastro, S.; Staffolani, N.; Pugliese, M.; D'Alo, F. 1994: An in-vitro study of the antimicrobial activity of copper and zinc salts on pure and mixed microbial cultures Minerva Stomatologica 43(9): 393-396
Schawrz, M.A.; Raith, K.; Dongowski, G.; Neubert, R.H. 1998: Effect on the partition equilibrium of various drugs by the formation of mixed bile salt/phosphatidylcholine/fatty acid micelles. A characterization by micellar affinity capillary electrophoresis. Part IV Journal of Chromatography A 809(1-2): 219-229
Ebrahimnejad, P.; Dinarvand, R.; Sajadi, S.A.; Atyabi, F.; Ramezani, F.; Jaafari, M.R. 2009: Preparation and characterization of poly lactide-co-glycolide nanoparticles of SN-38 PDA Journal of Pharmaceutical Science and Technology 63(6): 512-520
Chiara, G.; Rappelli, F. 1975: Studies on the in vitro spermicide activity and therapeutic use of a benzalkonium chloride base preparation (Agena) Minerva Ginecologica 27(11): 895-899
Li, J-juan.; Yang, G-de.; Wang, H-ying.; Zhang, S-qi. 2008: Preparation and liver targeting of floxuridinyl dibutyrate solid lipid nanoparticles Yao Xue Xue Bao 43(7): 761-765
Jankowska, E.; Łukaszewska, J. 2013: Potential exposure to silver nanoparticles during spraying preparation for air-conditioning cleaning Medycyna Pracy 64(1): 57-67
Huang, Y.; Chen, L.Y.; Li, Y.F.; Zhu, P.D. 1985: Study on the preparation and stability of solid dispersion of gossypol acetic acid-PVP and its spermicidal activity in vitro Yao Xue Xue Bao 20(12): 918-922
Toshkova, R.; Nikolova, N.; Ivanova, E.; Ivancheva, S.; Serkedjieva, J. 2004: In vitro investigation on the effect of a plant preparation with antiviral activity on the functions of mice phagocyte cells Die Pharmazie 59(2): 150-154