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Preparation and degradation behavior of PELGE nanoparticles

Duan, Y.; Zhang, Z.; Tang, Y.; Lin, Y.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 21(6): 921-925

2004

ISSN/ISBN: 1001-5515
PMID: 15646333
Document Number: 567978
A series of poly (lacticacid-co-glycolicacid)-poly(ethylene glycol) (PLGA-PEG, PELGA) block copolymers and poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene-glycol) (PELGE) was synthesized by ring-opening polymerization. PELGA nanoparticles and PELGE nanoparticles were prepared using the emulsion-solvent evaporation technique (O/W). To study the behavior and mechanism of the degradation of PELGA-NP and PELGA-NP, we determined the lactic acids by UV spectrophotometry. The method confirmed that degradation was much faster for polymers with a decrease in the LA content of the polymers or an increase in the PEG content of the polymers.

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