Pharmacokinetics of afobazole metabolite (M-11) in rats
Bastrygin, D.V.; Viglinskaia, A.O.; Kolyvanov, G.B.; Litvin, A.A.; Bochkov, P.O.; Mozhaeva, T.I.; Zherdev, V.P.
Eksperimental'naia i Klinicheskaia Farmakologiia 74(7): 22-26
2011
ISSN/ISBN: 0869-2092 PMID: 21894764 Document Number: 649104
Pharmacokinetics of compound M-11 (main metabolite of afobazole) after administration via different routes was studied in rats. After oral and intravenous administration, M-11 exhibited weakly pronounced bioconversion with the formation of a few metabolites that could be detected in plasma samples for about 3 hours. The absolute bioavailability of M-11 after oral administration was 68.3%. It was found that M-11 was completely absorbed from gastrointestinal tract of rats and characterized by "the first pass effect", after which approximately 70% of administered dose entered the circulation. The parent substance was determined neither in urine nor in feces.