Effects of silybinin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen in rats
Kim, C-Seong.; Choi, S-Jun.; Park, C-Young.; Li, C.; Choi, J-Shik.
Anticancer Research 30(1): 79-85
2010
ISSN/ISBN: 0250-7005 PMID: 20150620 Document Number: 640504
The effects of silybinin, an antioxidant, on the pharmacokinetics of tamoxifen and its metabolite, 4-hydroxytamoxifen, were investigated in rats. A single dose of tamoxifen was administered intravenously (2 mg/kg) and orally (10 mg/kg) without or with silybinin (0.5, 2.5 and 10 mg/kg) to rats. Silybinin significantly altered the pharmacokinetics of orally administered tamoxifen.
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