Model study of afobazole distribution in pregnant and lactating female rats and infant rat pups
Shreder, O.V.; Kolyvanov, G.B.; Litvin, A.A.; Bastrygin, D.V.; Shreder, E.D.; Solomina, A.S.; Viglinskaia, A.O.; Zabrodina, V.V.; Zherdev, V.P.; Durnev, A.D.; Seredenin, S.B.
Eksperimental'naia i Klinicheskaia Farmakologiia 73(8): 17-20
2010
ISSN/ISBN: 0869-2092 PMID: 20919552 Document Number: 645709
Afobazole and M-11, its major metabolite were detected in placental and embryonic rat tissues after single peroral administration to pregnant female rats at a dose of 100 mg/kg. The anxiolytic drug and its metabolite are also detected in rat milk and body of the breast-fed infant rat pups after 4 days of daily administration (200 mg/kg, per os) to lactating female rats.