Insertion/deletion polymorphism of angiotensin converting enzyme seriously modulates anesthetic outcome
Terada, K.
Masui. Japanese Journal of Anesthesiology 60(4): 408-415
2011
ISSN/ISBN: 0021-4892 PMID: 21520587 Document Number: 648779
The insertion/deletion (I/D) polymorphism of angiotensin converting enzyme is related to many serious disorders. We tested the hypothesis that the difference in I/D polymorphism strongly affects the clinical outcomes in surgical patients. After the IRB approval and the written informed consent, we studied 41 patients undergoing surgical repair of infrarenal abdominal aortic surgery. We allocated patients into one of two groups, patients with II and those with non-II (I/D and D/D) genotypes. All anesthetic management was strictly standardized. Preoperative patients' data, anesthetic management, and postoperative outcome were recorded by our fully-automatic electric chart system. The I/D polymorphism of ACE was detected by a gel electrophoresis after the conventional polymerase chain reaction. Genotype distributions of ACE-I/D were 39%, 51%, and 10% in genotypes II, ID, DD, respectively. Between-group differences were absent in all preoperative data. The duration of surgery was longer in patients with non-II genotypes than in those with II genotype. Postoperative infection was more common and the duration of ICU stay was longer in patients with non-II genotype than in those with II genotype. Our results reveal that patients with non-II genotype have more serious postoperative events than those with II genotypes.