Advanced achievements about neuroprotective mechanisms of paeoniflorin
Zhu, Y.; Dang, S.; Hua, Z.
Zhongguo Zhong Yao Za Zhi 35(11): 1490-1493
2010
ISSN/ISBN: 1001-5302 PMID: 20822028 Document Number: 647352
Paeoniflorin is one of the bioactive components of Paeonia lactiflora, a traditional Chinese herbal medicine. Some recent studies prove its distinguished neuroprotective effect. These neuroprotective mechanisms have become hot points and show closely correlated to activating adenosine A1 receptor, ameliorating the function of cholinergic nerve, regulating ion channel homeostasis, retarding oxidative stress and apoptosis of the neurocytes, promoting nerve growth, having an influence on astrocytes and being ableto penetrate though blood brain barrier. In this review, we present the neuroprotective mechanisms of paeoniflorin in the following eight aspects.