Neuroprotective effects of topiramate
Pappalardo, A.; Liberto, A.; Patti, F.; Reggio, A.
La Clinica Terapeutica 155(2-3): 75-78
2004
ISSN/ISBN: 0009-9074 PMID: 15244111 Document Number: 571734
Topiramate (TPM) is a new anti-convulsant drug, prescribed in epileptic seizure. Pharmacological actions of TPM are: a) a positive modulation of GABA receptors; b) inhibition of the kainite and aminohydroxymethylisoxazole propionic acid (AMPA) glutamate receptor sub-types; c) a use-dependent Na+ channel blocker. Recent studies suggest that TPM can have anti-excitotoxic properties, because it protects against motor neuron degeneration. Moreover, TPM enhances neuroprotection and reduces hemorrhagic incidence in focal cerebral ischemia.
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