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Neuroprotective effects of semax in MPTP-induced disturbances of brain dopamine system

Levitskaia, N.G.; Sebentsova, E.A.; Andreeva, L.A.; Alfeeva, L.I.; Kamenskiĭ, A.A.; Miasoedov, N.F.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 88(11): 1369-1377

2002

ISSN/ISBN: 0869-8139
PMID: 12587264
Document Number: 545806
Effects of an ACTH (4-10) analogue Semax (MEHFPGP) on behaviour of white rats with MPTP-induced disturbances of brain DA-system have been studied. It was shown that MPTP administration (25 mg/kg) reduced motor activity and auhmented the anxiety level in rats. Semax administration (daily intranasal 0.2 mg/kg) attenuated behaviour disturbances induced by neurotoxin. The observed protective action of Semax in rats with MFTP-induced DA system disturbances may be due to both its modulating influence on the brain DA system and peptide neuroprotective effects.

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