Effect of hemantane on bioelectric activity of brain in mice with MPTP-induced Parkinson syndrome
Kapitsa, I.G.; Kokshenev, I.I.; Nerobkova, L.N.; Val'dman, E.A.; Voronina, T.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 76(4): 3-6
2013
ISSN/ISBN: 0869-2092 PMID: 23762980 Document Number: 664790
A single intraperitoneal injection of MPTP neurotoxin (30 mg/kg) in C57BL/6 mice causes desynchronization of EEG with a decrease of theta-1 activity and a growth of beta activity in the interval of 15-30 Hz. Subchronic administration of the new antiparkinsonian drug hemantane (injection form) in a dose of 10 mg/kg makes the power of MPTP-induced beta oscillations less pronounced and leads to its reliable decrease within 24 h. This effect of hemantane administration was manifested during the entire period of observations.