Fibroblasts--known or unknown cells
Brychtová, S.; Bezdeková, M.; Brychta, T.
Ceskoslovenska Patologie 46(2): 29-32
2010
ISSN/ISBN: 1210-7875 PMID: 21280279 Document Number: 646140
Fibroblasts form the main component of the cell tissue microenvironment, and their basic function is to maintain cell integrity and tissue homeostasis. Fibroblasts essentially participate in wound repair. Recently, increased interest has been focused on the role of fibroblasts in cancers, where they are involved in the ransformation of a tumour stroma, and via production of numbers of cytokines and growth factors participate in tumour progression. With regard to their impact in cancerogenesis, fibroblasts become a new target of cancer therapy.