Reactions of hereophilic agglutinins with L-cells and different toxicity of anti-A HP to fibroblasts and L-cells in vitro
Schnitzler, S.; Karasek, E.; Mauersberger, B.; Oehme, P.; Buntrock, P.
Acta Biologica et Medica Germanica 35(10): 1385-1391
1976
ISSN/ISBN: 0001-5318 PMID: 1037185 Document Number: 105148
The carbohydrate binding glycoprotein Anti-AHP binds to the plasma membrane of the (transformed) L-cell both in agglutination reactions and by the immunofluorescence technique. On the surface of (normal) mouse embryo fibroblast cells Anti-AHP receptors were not detectable. Anti-AHP is suitable as another marker for L cells. The random distribution of the binding sites at 4 degrees C changes with elevated temperatures (clustering, capping of sites). Anti-AHP inhibits the growth of L cells much more than that of fibroblasts. It does not act as a mitogen for the investigated cells.