Research on phytoestrogenic effect of formononetin
Yu, J.; Zhao, P.; Niu, J.; Wang, J.; Cao, Y.; Hao, Q.
Zhongguo Zhong Yao Za Zhi 35(22): 3060-3064
2010
ISSN/ISBN: 1001-5302 PMID: 21355283 Document Number: 645152
Research on the phytoestrogenic effect and its possible mechanism of formononetin. To evaluate the estrogenic effect and mechanisms of formononetin through the test of its influence on proliferation and ER subtype expression of T47D cells. The proliferation rates of T47D cells treated with 1 x 10(-7) -1 x 10(-6) mol x L(-1) formononetin were not increased. On the influence of ICI182, 780, the proliferation rates of T47D cells treated with 1 x 10(-7) 1 x 10(-6) mol x L(-1) formononetin were decreased. Formonenetin could induce the augment of ERalpha expression significantly of T47D. Formonenetin has phytoestrogenic effect Formonenetin can not accelerate ER(+) T47D cell proliferation. But the expression level of ERalpha subtype in T47D cells change significantly with certain concentrations of formonenetin.