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Changes in various immunological parameters of lacrimal fluid in excessive scarring after antiglaucoma surgery in patients with primary open-angle glaucoma

Erichev, V.P.; Gankovskaia, L.V.; Koval'chuk, L.V.; Gankovskaia, O.A.; Dugina, A.E.

Vestnik Oftalmologii 126(3): 25-29

2010

ISSN/ISBN: 0042-465X
PMID: 20608195
Document Number: 644871
Twenty-two patients in whom the expression of the human beta-defensin-2 (HBD-2) gene and the concentrations of human neutrophil peptides (HNP 1-3) and interleukin-17 (IL-17) were determined in the conjunctiva and lacrimal fluid were followed. In patients with primary open-angle glaucoma, the baseline concentrations of HNP 1-3 and IL-17 in lacrimal fluid and the expression of the HBD-2 gene in the conjunctival epithelial cells were higher than those in healthy individuals. The appearance of signs of pathological scarring was observed when HBD-2 expression in the conjunctival epithelial cells was lower and the rate of changes in the lacrimal fluid concentrations of HNP 1-3 and IL-17 was stable.

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