Combined therapy and radiotherapy in stage-Ii Hodgkin disease
Il'in, N.V.; Vinogradova, I.N.; Nikolaeva, E.N.; Ivanova, E.I.; Shenderova, I.A.; Smirnova, E.V.; Izomov, B.M.; Trishkina, E.V.; Kritskaia, A.V.; Leenman, E.E.
Voprosy Onkologii 56(5): 623-626
2010
ISSN/ISBN: 0507-3758 PMID: 21137247 Document Number: 644593
The aim of the study was to raise efficacy of combined treatment of stage II Hodgkin's disease by optimization of fractionation and volume of irradiation. It included 179 patients with involvement of supradiaphragmatic lymph nodes treated in 1986-2006. It was found that multi-fractionation was followed by lower frequency of relapse as compared with standard regimens as well as rates of early ones. The most efficient dosage was 30-36 Gy as far as frequency, term of relapse occurrence and recurrence-free survival were concerned.