Leukocyte nitric oxide status in patients with chronic recurrent furunculosis
Novikova, I.A.; Gomoliako, A.V.
Klinicheskaia Laboratornaia Diagnostika 8: 34-36
2010
ISSN/ISBN: 0869-2084 PMID: 20886717 Document Number: 644055
The basal and in vitro pyrogenal-stimulated nitric oxide-producing capabilities of leukocytes versus their oxygen-producing and phagocytic activity were studied in patients with chronic recurrent furunculosis during remission (n=62) and exacerbation (n=12). The basal nitric oxide-producing activity of leukocytes was found to be similar. The stimulated leukocyte cultures from the patients showed mainly a perverted reaction--suppression of nitric oxide production instead of its increase detectable in donors. A direct correlation was found between the nitric oxide-producing activity of leukocytes and the results of HCT test in healthy individuals and patients during exacerbation rather than remission.