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Chronic occupational bronchitis in workers of coal extracting enterprises in Kouzbass: role of endogenous factors

Gafarov, N.I.; Zakharenkov, V.V.; Panev, N.I.; Burdeĭn, A.V.; Puzyrev, V.P.; Rudko, A.A.

Meditsina Truda i Promyshlennaia Ekologiia 3: 37-40

2010

ISSN/ISBN: 1026-9428
PMID: 20480820
Document Number: 642950
The authors studied distribution of biochemical markers for HP, GC, EsD, AcP genes, polymorphism of GSTT1 (GST-theta 1), GSTM1 (GST-mu 1), locus WNTR of NOS3 gene (alleles A/B) in chronic dust bronchitis patients and in apparently healthy individuals. Genotypes EsD 1-2 and AcP bb individuals were proved to be most prone to the disease. Endogenous resistent factors for chronic dust bronchitis are genotypes GC 1-1, EsD 1-1, AcP bc.

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