Clinical prognostic factors and outcome of surgical treatment in patients with early-stage bronchial carcinoid tumors
Stanic, J.; Zaric, B.; Anjelkovic, A.; Sarcev, T.; Eri, Z.; Boskovic, T.; Perin, B.
Journal of BUON Official Journal of the Balkan Union of Oncology 15(3): 524-528
2010
ISSN/ISBN: 1107-0625 PMID: 20941822 Document Number: 641772
Surgical resection is the treatment of choice for bronchial carcinoids (BC). The primary endpoint of this study was to look at the survival of patients with BC after the surgical treatment and to identify some clinicopathological prognostic factors influencing survival. The analysis included 57 patients with early- stage BC submitted to surgical treatment in the period 2000-2008. Major inclusion criteria were: pathologically confirmed BC, ECOG performance status 0-2, and surgical resection of the tumor. No significant difference in survival in relation to gender was registered. N0, N1 and N2 status was registered in 39, 9 and 2 patients, respectively. There were statistically significant differences in survival according to N status (p=0.032). Twenty-two patients had T1N0 stage, 21 T2N0, and 4 T1N1. There was a trend for significant differences in survival according to TN stage (p=0.063). Also, analysis revealed significant differences in survival depending on tumor size (p=0.000), as well as on the type of the tumor (typical vs. atypical) (p=0.010). Nodal status and TN stage affect patients' survival. Tumor size and typical/atypical tumor are also significant prognostic factors for survival of surgically treated patients.