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Regional treatment of esophageal liver metastasis by intra-arterial low-dose 5-FU therapy

Shuto, K.; Ohira, G.; Kono, T.; Natsume, T.; Tohma, T.; Sato, A.; Ota, T.; Saito, H.; Akutsu, Y.; Uesato, M.; Matsubara, H.; Okazumi, S.; Kaiho, T.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(12): 2409-2411

2010

ISSN/ISBN: 0385-0684
PMID: 21224589
Document Number: 641759
The prognosis of esophageal liver metastasis remains poor because of the high incidence of synchronous metastasis in other area and insufficient response to systemic chemotherapy. We assessed loco-regional anticancer potential of intra-arterial 5-FU chemotherapy for esophageal liver metastasis aimed at combination with systemic chemotherapy, radiotherapy and ablation therapy as a multidisciplinary treatment. Six patients of esophageal cancer with liver metastasis and without extra-hepatic metastasis were enrolled. Intra-aortic chemotherapy consisted of 5-FU (250 mg/body) in a one-shot infusion or a continuous infusion for 7 days with 2-week intervals until failure. The responses of liver metastasis were 2 cases of CR, 3 of PR and 1 of SD. The response rate and the local control rate were 83% and 100%, respectively. The maximum time to progression was 53 months. Grade 3/4 toxicity was not observed. Two cases had catheter failure and the treatment was interrupted. Liver metastases were controlled well until death in all cases except one. Low-dose intra-aortic 5-FU chemotherapy provided a good regional response and a combination with systemic chemotherapy may prolong survival for the patients of liver metastasis of esophageal cancer.

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