Antigenic activity of human herpes virus type 8 proteins coding orfK8.1 and orf65
Kornienko, N.V.; Pimenov, V.K.; Gladysheva, M.V.; Ulanova, T.I.; Puzyrev, V.F.; Burkov, A.N.; Obriadina, A.P.
Voprosy Virusologii 54(3): 45-48
2009
ISSN/ISBN: 0507-4088 PMID: 19537097 Document Number: 637844
A peptide scanning of the sequences of human herpes virus type 8 (HHV-8) proteins coding orfK8.1 and orf65 was made. The antigenic activity of peptides was evaluated by ELISA. The fragment 101-213 aa of orfK8.1-encoded protein was shown to consist of two sites containing linear B-epitopes that had a weak antigenic activity: 121-145 and 177-209 aa. The protein coding orf65 comprised 2 sites at which linear B-cell epitopes 78-110 aa (a weak antigenic activity) and 142-170 aa (a strong antigenic activity) were located.
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