Clinico-biochemical effectiveness of emoxpine in patients with bacterial bronchial asthma
Lapik, S.V.; Zhmurov, V.A.
Terapevticheskii Arkhiv 70(11): 72-74
1998
ISSN/ISBN: 0040-3660 PMID: 9949468 Document Number: 6363
To determine effectiveness of a synthetic antioxidant drug emoxipine in combined treatment of bacterial bronchial asthma (BBA). A total of 59 BBA patients were treated who had the disease for 1-14 years. The previous treatment consisted of bronchodilating, mucolytic and expectorant drugs. 19 of them received i.m. adjuvant emoxipine for 10 days in daily dose 0.3 mg/kg as a 1% aqueous solution. Metabolic activity of alveolar macrophages (AM) was measured. Emoxipine-treated patients had reduced content of primary lipid peroxidation products and schiff bases in AM, catalase level in them returned to normal, blood levels of alpha-tocopherol went up. Emoxipine is beneficial for AM antioxidant defence system in BBA patients.
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