Coronary artery disease attack caused by cytotoxic chemotherapy
Ilveskoski, E.; Nikus, K.; Tanner, M.; Eskola, M.
Duodecim; Laaketieteellinen Aikakauskirja 125(9): 997-1001
2009
ISSN/ISBN: 0012-7183 PMID: 19517869 Document Number: 635976
Capesitabine is a orally administered cytotoxic drug metabolized to 5-fluorouracil and is widely used in large intestine cancer and breast cancer therapy. Its adverse effects against the heart have been considered to be rare. We describe four patients, who were diagnosed with an attack of coronary artery disease during capesitabine therapy on the basis of coronary spasm. This adverse effect should be kept in mind as a cause of chest pain symptoms and the medication discontinued in a suspected case.
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