Clinical and neurophysiological manifestations of cerebral asymmetry in cervical dystonia
Naryshkin, A.G.; Skoromets, T.A.; Gorelik, A.L.; Egorov, A.I.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 109(10): 51-56
2009
ISSN/ISBN: 1997-7298 PMID: 20037571 Document Number: 635406
Based on the analysis of clinical and neurophysiological data with the use of up-to-date methods of EEG processing, the authors discuss a role of cerebral asymmetry (CA) in the pathogenesis of cervical dystonia (CD). Sixty-seven patients (31 male and 36 female) with CD have been studied. The pathological turn of the head to the right side (RT) was observed in 34 patients, to the left side (LT) - in 33 patients. The uni- or bilateral generalization of dystonic symptoms (Meig's syndrome, laterocollis) was found only in one-third of RT patients. The visual analysis of EEG of RT patients revealed the high level of EEG synchronization with signs of cortical irritation, with the prevalence in the left hemisphere, and the presence of focal epileptiform appearances in the temporal leads of the left or both hemispheres with the left-side prevalence. In LT patients, the EEG presentation was similar to normal but more often represented the variants of <> EEG-pattern. In these cases, the apparent manifestations of CA were not found. The coherent analysis revealed the formation of the network of <> coherent links, with bilateral spread, in RT patients. This may suggest the functional inequivalence of the peripersonal space of right and left hand and the dominate significance of striopallidar and thalamic structures of the left hemisphere for the total brain activity.