Top Abstract Purchase Related
Home
>
Node
>
Subnode

Effect of temperature and time on stability of ketamine in biological samples

Cao, J.; Wang, Z.-H.; Jia, J.; Yun, K.-M.; Wei, Z.-W.; Wang, Y.-J.

Fa Yi Xue Za Zhi 25(6): 434-436

2009

ISSN/ISBN: 1004-5619
PMID: 20225620
Document Number: 635352
The stability of ketamine in biological samples was studied under different storage temperature and time. The rabbits were given intragastric administration of ketamine with a dose of 150 mg/kg and were sacrificed after 30 minutes. Blood, liver, kidney and brain of the rabbits were stored at room temperature (between 18 degrees C and 24 degrees C) and -20 degrees C. The specimens were analyzed at different times by GC-MS and GC-NPD. At -20 degrees C, the concentration of ketamine decreased in all of samples (P < 0.05) within 30 days. The concentration of ketamine increased in all of samples stored at room temperature after 5 days(P < 0.05). The stability of ketamine in biological samples stored at -20 degrees C was better than that at room temperature. The samples suspected containing ketamine should be stored at -20 degrees C and should be tested as soon as possible.

Document emailed within 1 workday
Secure & encrypted payments

Smith, B.R. 1983: Effect of storage temperature and time on stability of cefmenoxime, ceftriaxone, and cefotetan in 5% dextrose injection American Journal of Hospital Pharmacy 40(6): 1024-1025
Sochava, I.V.; Smirnova, O.I.; Barynin, V.V.; Belopol'skaia, T.V.; Kazitsyna, S.I. 1982: Temperature and time stability of proteins in concentrated solutions Molekuliarnaia Biologiia 16(2): 386-391
Shawesh, A.M.; Kaukonen, A.; Kallioinen, S.; Antikainen, O.; Yliruusi, J. 2003: Development of indomethacin Carbopol ETD 2001 gels and the influence of storage time and temperature on their stability Die Pharmazie 58(2): 130-135
Fritzsche, I.; Buehrdel, P.; Melcher, R.; Hans-Joachim Boehme 2001: Stability of Ketone Bodies in Serum in Dependence on Storage Time and Storage Temperature Clinical Laboratory 42(7-8): 399-403
Nguyen, M.T.; Oey, I.; Hendrickx, M.; Van Loey, A. 2006: Effect of pressure and temperature combination on the stability of (6R,S) 5-methyl and (6R,S) 5-formyltetrahydrofolic acid in model system Communications in Agricultural and Applied Biological Sciences 71(1): 291-295
Carlos García, R.; Rodríguez Sasiain, J.M.; Santafé Oroz, J.; Quintana Loyola, A.; Segarra Doménech, J. 1976: Acute tolerance and time changes in ketamine-induced sleep under the effect of phenobarbital and chlorophenicol. Experimental study Revista Espanola de Anestesiologia y Reanimacion 23(1): 57-67
Ohkawa, H.; Iwakawa, T.; Ohtomo, N.; Kitayama, M.; Miyahara, A.; Matsuki, A. 1993: Clinical study on total intravenous anesthesia with droperidol, fentanyl, and ketamine--18. Effect on peripheral circulation as judged by core-peripheral temperature gradient Masui. Japanese Journal of Anesthesiology 42(4): 557-561
Efimov, A.V. 1987: Protein stability to the effect of denaturing agents and elevated temperature is directly proportional to the fraction of hydrophobic residues in its molecule Molekuliarnaia Biologiia 21(1): 62-72
Shumada, I.V.; Krivenko, V.M.; Perfilova, T.N.; Beletskiĭ, N.I. 1970: Effect of the length of time of preservation on the stability of the femoral bone Ortopediia Travmatologiia i Protezirovanie 31(9): 18-20
Meyer, W.J.; Gauthier, D.W. 1992: Effect of time and storage temperature on amniotic fluid glucose concentration Obstetrics and Gynecology 80(6): 1017-1019
Venz, S.; Dermann, K. 1984: Effect of the setting time and polish on the stability and corrosion behavior of dental amalgams Deutsche Zahnarztliche Zeitschrift 39(5): 360-363
Badimón, L.; Villaverde, C.A.; Vidal, M.; Badimón, J.J.; Miret, M. 1981: Inhibitors of the fibrinolytic system in various animal species and the effect of time and temperature on their preservation Archivos de Farmacologia y Toxicologia 7(1): 101-104
Nishiyama, M.; Hayashi, S.; Kabutomori, O.; Yamanishi, H.; Suehisa, E.; Kurata, Y.; Kashiwagi, H.; Tomiyama, Y. 2011: Effects of anticoagulants and storage temperature on immature platelet fraction % (IPF%) values in stored samples measured by the automated hematology analyzer, XE-5000--utility of CTAD-anticoagulation and room temperature storage Rinsho Byori. Japanese Journal of Clinical Pathology 59(5): 452-458
Whang, L.M.; Park, J.K. 2002: Competition between polyphosphate- and glycogen-accumulating organisms in biological phosphorus removal systems--effect of temperature Water Science and Technology: a Journal of the International Association on Water Pollution Research 46(1-2): 191-194
Piedras, J.; Sánchez-Montero, P.E.; Herrera, F.M.; Córdova, M.S.; Sánchez-Medal, L. 1993: Effect of plasma freezing temperature, anticoagulant and time of storage on factor VIII:C activity in cryoprecipitate Archives of Medical Research 24(1): 23-26
Lin, J.F. 1988: Effect of pH, NaCl, temperature and time of incubation on the probability of Vibrio parahaemolyticus growth initiation in a model broth Acta Veterinaria Scandinavica. Supplementum 84: 283-286
Hamosh, M.; Ellis, L.A.; Pollock, D.R.; Henderson, T.R.; Hamosh, P. 1996: Breastfeeding and the working mother: effect of time and temperature of short-term storage on proteolysis, lipolysis, and bacterial growth in milk Pediatrics 97(4): 492-498
El-Banna, H.M.; Boraie, N.; El-Shibini, H.A. 1981: The construction and uses of factorial designs in the preparation of solid dosage forms. Part 3. Effect of temperature and time on the mechanical properties of sintered tablets Die Pharmazie 36(11): 772-775
Tarasiuk, A.; Skierski, J.; Kazimierczuk, Z. 1994: Stability of 2-chloro-2'-deoxyadenosine at various pH and temperature Archivum Immunologiae et Therapiae Experimentalis 42(1): 13-15
Sasanakul, W.; Chuansumrit, A.; Rurgkhum, S.; Udomsubpayakul, U.; Hathirat, P. 1999: DNA extraction and amplification of 10-day, room-temperature blood samples Journal of the Medical Association of Thailand 82(Suppl 1): S186-S189