Two cases of recurrent oral cancer responding to radiochemotherapy with selective intra-arterial infusion of nedaplatin
Yamashita, Y.; Kuroda, Y.; Yamamoto, T.; Goto, M.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 36(4): 631-635
2009
ISSN/ISBN: 0385-0684 PMID: 19381037 Document Number: 634398
Nedaplatin, a cisplatin derivative, has been reported to be an effective anti-tumor agent for head and neck cancer. We experienced two patients with advanced recurrent oral cancers who received combination therapy of intra-arterial nedaplatin infusion and radiation therapy, and tumoricidal effects were obtained in these cases. At the end of 3 courses, a partial response(PR)was obtained with regression of the tumor in the first case, and FDGPET showed a complete regression of recurrent tumor for a complete response(CR)in another case. This combination therapy is quite safe and effective for the treatment of advanced oral cancers.
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