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Clinical significance of some genetic polymorphisms of cytochrome P-450: family CYP1 and subfamilies CYP2A, CYP2B and CYP2C

Wojtczak, A.; Skretkowicz, J.

Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 26(153): 248-252

2009

ISSN/ISBN: 1426-9686
PMID: 19388543
Document Number: 633976
The essence of pharmacogenetic studies is to provide a scientific explanation for personal differences in the process of drugs metabolism. Polymorphism of drugs biotransformation is clinically significant from the point of view of the effectiveness and safety of pharmacotherapy and an increased risk of some illnesses. The paper presents molecular mechanisms and clinical implication of several genetic polymorphisms of cytochrome P-450 (CYP) xenobiotics metabolizing enzymes and genetic predisposition to the occurrence of some diseases.

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Wojtczak, A.; Skretkowicz, J. 2009: Clinical significance of some genetic polymorphisms of cytochrome P-450 subfamilies CYP2D, CYP2E and CYP3A--part Ii Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego 27(158): 166-169
Murata, M. 2001: Clinical significance and strategies to analyze genetic polymorphisms Rinsho Byori. Japanese Journal of Clinical Pathology 49(2): 153-156
Matchar, D.B.; Thakur, M. 2007: Is genetic testing for cytochrome P450 polymorphisms ready for implementation? American Family Physician 76(3): 348; 351
Ambrosone, C.B.; Freudenheim, J.L.; Graham, S.; Marshall, J.R.; Vena, J.E.; Brasure, J.R.; Laughlin, R.; Nemoto, T.; Michalek, A.M.; Harrington, A. 1995: Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorphisms and postmenopausal breast cancer risk Cancer Research 55(16): 3483-3485
Corcos, L. 1992: Phenobarbital and dexamethasone induce expression of cytochrome P-450 genes from subfamilies IIB, IIC, and IIIA in mouse liver Drug Metabolism and Disposition: the Biological Fate of Chemicals 20(6): 797-801
Shavkunov, A.S.; Lazarev, V.N.; Chernausova, L.N.; Kuz'min, A.V.; Govorun, V.M. 2002: Genetic heterogeneity of cytochrome CYP51 in clinical strains of Mycobacterium tuberculosis Voprosy Meditsinskoi Khimii 48(4): 361-367
Tomaiuolo, A.Cristina.; Alghisi, F.; Petrocchi, S.; Surace, C.; Roberti, M.Cristina.; Bella, S.; Lucidi, V.; Angioni, A. 2010: Clinical hallmarks and genetic polymorphisms in the CFTR gene contribute to the disclosure of the A1006E mutation Clinical and Investigative Medicine. Medecine Clinique et Experimentale 33(4): E234-E239
Brøsen, K. 1991: The significance of cytochrome P450 gene superfamily for the clinical pharmacokinetics of drugs Ugeskrift for Laeger 153(6): 417-422
Wang, Y-Yuan.; Zhang, M.; Lu, F-Ming.; Jiao, Z.; Qiu, X-Yan. 2012: CYP3A4 genetic polymorphisms predict cyclosporine-related clinical events in Chinese renal transplant recipients Chinese Medical Journal 125(23): 4233-4238
Väisänen, S.; Rauramaa, R.; Penttilä, I.; Rankinen, T.; Gagnon, J.; Pérusse, L.; Chagnon, M.; Bouchard, C. 1997: Variation in plasma fibrinogen over one year: relationships with genetic polymorphisms and non-genetic factors Thrombosis and Haemostasis 77(5): 884-889
Mori, M.; Nakashima, H.; Mimori, K.; Tanaka, Y.; Mafune, K.; Ueo, H.; Sugimachi, K.; Akiyoshi, T. 1996: Clinical significance of genetic instability in gastrointestinal cancers Nihon Rinsho. Japanese Journal of Clinical Medicine 54(4): 1025-1030
Yoshimura, M.; Tsubota, N.; Miyamoto, Y.; Nakamura, H.; Minami, H.; Toyama, I. 1997: Genetic analysis and clinical significance of heterotopic hCGbeta production in lung cancer Nihon Kyobu Geka Gakkai 45(3): 392-393
Agostinho, L.A.; Spitz, M.; Pereira, J.S.; Paiva, C.L.A. 2016: Clinical and genetic investigation of a Brazilian family with Huntington's disease Functional Neurology (): 1-8
Checkoway, H.; Farin, F.M.; Costa-Mallen, P.; Kirchner, S.C.; Costa, L.G. 1998: Genetic polymorphisms in Parkinson's disease Neurotoxicology 19(4-5): 635-643
Takebe, H. 2003: Bioethics in studies on genetic polymorphisms Gan to Kagaku Ryoho. Cancer and ChemoTherapy 30(1): 155-160
Omoto, K.; Tokunaga, K. 1982: Genetic polymorphisms of complement systems in Japanese Jinrui Idengaku Zasshi. Japanese Journal of Human Genetics 27(2): 73-79
Wu, M-Shiang.; Chen, C-Jen.; Lin, J-Town. 2003: Genetic alterations and polymorphisms in gastric cancer Journal of the Formosan Medical Association 102(7): 447-458
Sripichai, O.; Fucharoen, S. 2007: Genetic polymorphisms and implications for human diseases Journal of the Medical Association of Thailand 90(2): 394-398
Higaki, J.; Katsuya, T.; Ogihara, T. 2001: Genetic polymorphisms of the renin-angiotensin system Nihon Rinsho. Japanese Journal of Clinical Medicine 59(5): 847-852
Kim, C.H.; King, T.E. 1991: Effect of pyridoxal phosphate on the formation of cytochrome c1-c and cytochrome c-cytochrome oxidase complexes Biochemistry International 24(2): 255-262