Genetic polymorphisms of the renin-angiotensin system
Higaki, J.; Katsuya, T.; Ogihara, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 59(5): 847-852
2001
ISSN/ISBN: 0047-1852 PMID: 11391981 Document Number: 527973
Essential hypertension is a multifactorial disease which is evoked by multiple environmental and genetic factors. Recent progress in molecular biology enables us a comprehensive understanding of the molecular pathogenesis of this disease. The genes of renin-angiotensin system such as renin, angiotensinogen, angiotensin-converting enzyme and angiotensin receptors genes are all reported as positive linkage to hypertension. Now ongoing progress of the human genome project will further accelerate the molecular studies on the rennin-angiotensin system and hypertension.