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Clinical significance of some genetic polymorphisms of cytochrome P-450 subfamilies CYP2D, CYP2E and CYP3A--part Ii

Wojtczak, A.; Skretkowicz, J.

Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 27(158): 166-169

2009

ISSN/ISBN: 1426-9686
PMID: 19856888
Document Number: 631027
Polymorphism of drugs biotransformation is clinically significant from the point of view of the effectiveness and safety of pharmacotherapy and an increased risk of some illnesses. The paper presents molecular mechanisms and clinical implication of several genetic polymorphisms of cytochrome P-450 (CYP) xenobiotics metabolizing enzymes and genetic predisposition to the occurrence of some diseases.

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