Effect of lipopolysaccharide and hypoxia on rat neutrophils in vitro
Salwińska, M.; Uracz, D.; Uracz, W.
Folia Medica Cracoviensia 50(3-4): 5-20
2009
ISSN/ISBN: 0015-5616 PMID: 21853867 Document Number: 632717
The main aim of this study was to examine the role of lipopolysaccharide (LPS) and hypoxia on respiratory burst in rat neutrophils in vitro. Hypoxia (2% oxygen tension) inhibited respiratory burst of neutrophils in response to phorbol ester. Neutrophils treatment by LPS and hypoxia resulted in significant augmentation respiratory burst via NADPH oxidase activity in luminol chemiluminescence. This paper suggests that induction of iNOS was responsible for this effect.
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