A successfully resected case of rectal cancer with liver metastases treated with mFOLFOX6 and bevacizumab
Fujita, T.; Kawasaki, K.; Ohno, M.; Kanaji, S.; Kobayashi, I.; Ueno, K.; Tsuchida, S.; Osawa, M.; Fujino, Y.; Kanbara, Y.; Nakamura, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 36(4): 663-666
2009
ISSN/ISBN: 0385-0684 PMID: 19381044 Document Number: 632591
A sixties-man had complained of melena. Colonoscopy revealed type 2 tumor at rectum. Computed tomography (CT)demonstrated lymph node metastasis in front of sacrum and two low density areas which were suspected metastases in the liver. The patient was diagnosed stageIV rectal cancer and resected primary focus and lymph node metastasis.[ Ra-RS, ant, type 2, moderately differentiated adenocarcinoma, ly1, v3, pSE, pN2, sH1(Grade C), sP0, pM1(No. 270)]without liver resection. It was due to high level of CEA and remote lymph node metastasis. The patient was treated with mFOLFOX6 and bevacizumab after the operation. The level of CEA decreased to normal level and CT revealed a partial response after 4 cycles of systemic chemotherapy. Liver resection was performed safely. Histological response was Grade 2 at liver metastases.