A case of cecum colon cancer with lymph node metastasis successfully treated with XELOX plus bevacizumab
Ito, S.; Ichikawa, R.; Kure, K.; Honjo, K.; Aoki, J.; Okazawa, Y.; Mizukoshi, K.; Ro, H.; Kawai, M.; Takehara, K.; Okubo, H.; Ishiyama, S.; Sugimoto, K.; Komiyama, H.; Takahashi, M.; Yaginuma, Y.; Kojima, Y.; Goto, M.; Tomiki, Y.; Sakamoto, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 41(11): 1425-1428
2014
ISSN/ISBN: 0385-0684 PMID: 25434448 Document Number: 678864
A 65-year-old woman with a history of constipation presented at our hospital and was subsequently diagnosed with advanced cecum cancer. We performed laparoscopic right hemicolectomy in January 2009, with pathological findings reveal- ing the presence of Stage III b (pT3, pN3, cM0, Cur A) disease. The patient was treated with a uracil/tegafur plus Leucovorin (UFT/LV) adjuvant chemotherapy regimen for six months. In June 2010, bold examination indicated an elevated level of tumor marker CA19-9. Computed tomography (CT) and positron emission tomography (PET)/CT revealed Virchow's and para-aortic lymph node metastasis. Therapy with XELOX and bevacizumab (Bmab) was administered and continued for 10 cycles. Capecitabine+Bmab treatment was also administered for 11 courses due to an adverse event of peripheral neuropathy. Follow-up revealed both the Virchow's and para-aortic lymph node metastasis had disappeared upon completion of treatment. In November, 2011 the patient was considered to have achieved a clinical complete response (CR) and continues to be followed with no further disease progression.