Diagnosis and treatment of primary pigmented nodular adrenocortical disease report of 4 cases
Liu, G-Hua.; Li, H-Zhong.; Mao, Q-Zong.; Ji, Z-Gang.; Xia, M.; Xie, Y.; Hu, M-Ming.; Liu, Y-Wu.
Zhonghua Yi Xue Za Zhi 89(30): 2138-2139
2009
ISSN/ISBN: 0376-2491 PMID: 20058620 Document Number: 632151
To study the diagnosis and treatment of primary pigmented nodular adrenocortical disease (PPNAD). The clinical data including symptom, endocrinal examination, surgical operation and prognosis of 4 cases of PPNAD hospitalized from 2000 to 2007 were analyzed respectively, relative literature were reviewed. 1 case received total adrenalectomy needed adrenocortical hormone postoperatively, 3 cases responded favorably to subtotal adrenalectomy and did not need adrenocortical hormone, however, 1 case was diagnosed of thyroid carcinoma 2 years after subtotal adrenalectomy. PPNAD is a rare subtype of ACTH-independent Cushing's syndrome, the diagnosis is depend on symptom, endocrinal examination and pathology. Total adrenalectomy is suitable to the patients with obvious symptom; subtotal adrenalectomy to the patients with mild symptom, the lesion of other endocrinal organ must be followed up postoperatively.