Drug discovery based on classic natural products
Hu, L-hong.; Xu, J-qing.
Yao Xue Xue Bao 44(1): 11-18
2009
ISSN/ISBN: 0513-4870 PMID: 19350815 Document Number: 630716
We think the strategy of classic natural product-based drug discovery will be an effective way for us to develop new drugs with independent intellectual property. The strategy includes: to study the molecular mechanism of action of classic natural product with chemical genetics and chemical biology approaches firstly; then establish the proper in vitro bioassay or bioassay system based on its molecular mechanism for their pharmacodynamic evaluation; finally, study their structure-activity, structure-toxicity and structure-ADME properties with medicinal chemistry.