Evaluation of detection of Epstein-Barr virus Rta/IgG in nasopharyngeal carcinoma
Zheng, Y.-M.; Cain, Y.-L.; Cheng, J.-R.; Li, J.; Mo, Y.-K.; Gao, J.-Q.; Dong, Z.-R.; Zhong, Q.-Y.
Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 23(4): 285-287
2009
ISSN/ISBN: 1003-9279 PMID: 20108775 Document Number: 629813
This study was aimed to investigate the clinical value of Epstein-Barr virus (EBV) Rta/IgG in the diagnosis of nasopharyngeal carcinoma (NPC). Serum samples derived from 211 untreated patients with NPC, 413 subjects including 203 non-NPC ENT patients and 210 healthy volunteers as control were examined for the presence of antibodies directed against Rta/IgG by using enzyme-linked immnunosorbent assay (ELISA). Receiver operating characteristic (ROC) curve was applied to perform methodical evaluation of this tumor marker. The rA value median of Rta/IgG in NPC group was significantly higher than one in control group (P < 0.001). The area under ROC was 0.933. The sensitivity and specificity of this marker were 90.5% and 90.1%, respectively, when the best cutoff value was defined. Rta/IgG detected with ELISA method is a new target of EBV, and may be one of important marker for NPC diagnosis.