The effect of Epstein-Barr virus gene BHRF1 expression on the apoptotic resistance of nasopharyngeal carcinoma cells
Huang, H.; Pan, X.; Yu, L.
Zhonghua Zhong Liu Za Zhi 20(4): 245-247
1998
ISSN/ISBN: 0253-3766 PMID: 10920973 Document Number: 485198
To investigate the effect of EB virus gene BHRF1 expression on the apoptotic resistance of nasopharyngeal carcinoma cell. Expression vector for BHRF1 was constructed and transfected into nsaopharyngeal carcinoma cell line, CNE2. The alteration of biologic behaviour of the transfected cells was tested after 60Co radiation. BHRF1 expression could inhibit the expression of proliferative cell nuclear antigen, redistribute cell cycle, decrease cell sensitivity to radiation, and enhance their survival ability. It is suggested that BHRF1 expression can increase the apoptotic resistance induced by radiation.