Transfer factor specific to mouse lung carcinoma of Lewis
Grinevich, I.A.; Fil'chakov, F.V.; Shumilina, E.C.; Lën, A.D.; Shved, V.V.
Voprosy Onkologii 55(5): 612-618
2009
ISSN/ISBN: 0507-3758 PMID: 20020659 Document Number: 629238
Factor of transfer was identified and sampled in the course of immunization of rats with cells or tissues of mouse lung carcinoma of Lewis and its antitumor action investigated on models of passive and spontaneous dissemination in mice C57BL/6. Samples obtained at the peak of immunological response (day 14) and immunological memory inception (day 60) were shown to be capable of marked antimetastatic effects: fall in metastatic frequency, number and size of metastases correlated with higher index of metastasis formation.