Lymphocytic-thrombocytic adhesion and production of blood serum cytokines in rheumatic heart disease
Gorbunov, V.V.; Tsarenok, S.I.; Rosin, I.V.
Terapevticheskii Arkhiv 80(12): 37-39
2008
ISSN/ISBN: 0040-3660 PMID: 19227905 Document Number: 627890
To study changes of cytokine production and lymphocytic-thrombocytic adhesion (LTA) in patients with rheumatic heart disease. Concentrations of interleukine-1beta, interleukine-4, tumor necrosis factor alpha in the blood serum and lymphocytic-thrombocytic adhesion by Yu. A. Vitkovsky's method were measured in 84 patients with rheumatic fever and 26 healthy ones. A correlation was found between increased production of inflammatory cytokines, lymphocytic-thrombocytic adhesion and activation of rheumatic process. A monodirection of changes of inflammatory cytokine production, lymphocytic-thrombocytic adhesion and rheumatic fever activation allows using them as nonspecific diagnostic methods in assessment of inflammation activity.