Serum proinflammatory cytokines and adhesion molecules in ulcerative colitis
Umehara, Y.; Kudo, M.; Nakaoka, R.; Kawasaki, T.; Shiomi, M.
Hepato-Gastroenterology 53(72): 879-882
2006
ISSN/ISBN: 0172-6390 PMID: 17153445 Document Number: 2608
Background/Aims: The aim of this study was to define the correlation between serum markers, such as proinflammatory cytokines and adhesion molecules, and disease activity in ulcerative colitis (UC).Methodology: Nineteen patients with UC treated in our hospital from April 2003 to June 2004, were enrolled into this study. We measured serum interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule (VCAM-1) from a blood sample. We investigated the correlation between these cytokine molecules and clinical activity.Results: Serum levels of IL-6 after treatment were significantly decreased proportionately as disease activity improved. Serum levels of IL-8 also significantly correlated with disease activity. On the other hand, serum levels of TNF-alpha were within the normal range in most of cases despite being in the active phase. There were also no significant differences between before and after treatment in serum levels of ICAM-1 or VCAM-1.Conclusions: Serum IL-6 and IL-8 significantly reflected disease activity in patients with UC.
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