Chronotropic activity of semax
Arushanian, E.B.; Popov, A.V.
Eksperimental'naia i Klinicheskaia Farmakologiia 71(2): 14-16
2008
ISSN/ISBN: 0869-2092 PMID: 18488900 Document Number: 622144
The chronic administration of nootropic drug Semax, a peptide analog of ACTH (4-10), normalized the circadian locomotor rhythm in rats (with an increase in its amplitude, a shift in the acrophase, and a change of the spectral characteristics) and reduced the integral chronobiological index. It is suggested that the rhythm-synchronizing chronotropic activity may be a part of the specific effect of this cognitive enhancer.