The negative chronotropic effect of isorhynchophylline and its mechanism
Zhu, Y.
Zhongguo Zhong Yao Za Zhi 18(12): 745
1993
ISSN/ISBN: 1001-5302 PMID: 8011087 Document Number: 419608
Isorhynchophylline (2-4 mg/kg i.v.) can produce a negative chronotropic effect in rats without influencing blood pressure. This negative chronotropic effect has nothing to do with cardiac M, beta and H2 receptors, but may be related to the block of calcium.
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